Centromeres: Old tales and new tools

Tales of Tools and Trees

In this paper, I study the application of phylogenetic analysis in evolutionary archaeology. I show how transfer of this apparently general analytic tool is affected by salient differences in disciplinary context. One is that archaeologists, unlike many biologists, do not regard cladistics as a tool for classification, but are primarily interested in explanation. The other is that explanation i...

Imaging zinc: old and new tools.

As recently as 20 years ago, all zinc in biological systems was believed to be tightly bound to proteins, and the idea of imaging zinc was considered heretical. Beginning with Maske's research with dithizonate staining of the hippocampus in the 1950s, however, zinc-sensitive dyes have indicated that, in mammalian cells, free zinc can exist in at least three separate pools. These pools include v...

New tools for an old disease.

An Old Insight Leads to New Tools

seems an unlikely person to help transform the statistical rigor of experiments in the vanguard of microarray analyses and proteomics. For one thing, he died almost 250 years ago in Tunbridge Wells, an English town that remains sleepy even today. And rather than being a scientist, Bayes was a nonconformist minister. Yet today's microarray and proteomic researchers increasingly use the statistic...

Old Tales Retold with Fresh Comments

Prices reached famine rates. Rice 9 seers 2 4|7 chittacks the rupee. Salt only the usual Price, 2 annas a seer. The Brahmaputra swollen as never before. Ominous predictions heard everywhere. (Daily Press, 1953). (2) From Indore, dated August 24, 1878. Rainfall abundant but everything sold at exorbitant rates: wheat at 10 seers, coarse rice at 8 seers, better rice at 6 seers, gram at 10 seers an...